The Superficial Stromal Scar Formation Mechanism in Keratoconus: A Study Using Laser Scanning In Vivo Confocal Microscopy
Joint Authors
Liu, Ting
Gao, Hua
Sui, Wenjie
Song, Peng
Wang, Shuting
Zhang, Peicheng
Zhang, Yangyang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
To investigate the mechanism of superficial stromal scarring in advanced keratoconus using confocal microscopy, the keratocyte density, distribution, micromorphology of corneal stroma, and SNP in three groups were observed.
Eight corneal buttons of advanced keratoconus were examined by immunohistochemistry.
The keratocyte densities in the sub-Bowman’s stroma, anterior stroma, and posterior stroma and the mean SNP density were significantly different among the three groups.
In the mild-to-moderate keratoconus group, activated keratocyte nuclei and comparatively highly reflective ECM were seen in the sub-Bowman’s stroma, while fibrotic structures with comparatively high reflection were visible in the anterior stroma in advanced keratoconus.
The alternating dark and light bands in the anterior stroma of the mild-to-moderate keratoconus group showed great variability in width and direction.
The wide bands were localized mostly in the posterior stroma that corresponded to the Vogt striae in keratoconus and involved the anterior stroma only in advanced keratoconus.
Histopathologically, high immunogenicity of α-SMA, vimentin, and FAP was expressed in the region of superficial stromal scarring.
In vivo confocal microscopy revealed microstructural changes in the keratoconic cone.
The activation of superficial keratocytes and abnormal remodeling of ECM may both play a key role in the superficial stromal scar formation in advanced keratoconus.
American Psychological Association (APA)
Song, Peng& Wang, Shuting& Zhang, Peicheng& Sui, Wenjie& Zhang, Yangyang& Liu, Ting…[et al.]. 2016. The Superficial Stromal Scar Formation Mechanism in Keratoconus: A Study Using Laser Scanning In Vivo Confocal Microscopy. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098702
Modern Language Association (MLA)
Song, Peng…[et al.]. The Superficial Stromal Scar Formation Mechanism in Keratoconus: A Study Using Laser Scanning In Vivo Confocal Microscopy. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098702
American Medical Association (AMA)
Song, Peng& Wang, Shuting& Zhang, Peicheng& Sui, Wenjie& Zhang, Yangyang& Liu, Ting…[et al.]. The Superficial Stromal Scar Formation Mechanism in Keratoconus: A Study Using Laser Scanning In Vivo Confocal Microscopy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098702
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098702