β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation
Joint Authors
Chen, Wen-Liang
Tai, Chun San
Chen, Yi Yun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
β-Lactoglobulin (LG) is suspected to enhance or modulate human immune responses.
Moreover, LG is also hypothesized to increase human cell proliferation.
However, these potential functions of LG have not been directly or thoroughly addressed.
In this study, we demonstrated that LG is a potent stimulator of cell proliferation using a hybridoma cell (a splenocyte fused with a myeloma cell) model.
LG’s ability to promote cell proliferation was lost when the protein is denatured.
To further investigate the influence of LG’s conformation on cell proliferation, we chemically modified LG by either carboxymethylation (CM) or acetylation and observed significantly reduced cell proliferation when the protein structure was altered.
Furthermore, we proved that LG enhances cell proliferation via receptor-mediated membrane IgM receptor.
These data indicated that nondenatured LG is the major component in milk that modulates cell proliferation.
Collectively, our study showed that LG plays a key role in enhancing immune responses by promoting cell proliferation through IgM receptor.
American Psychological Association (APA)
Tai, Chun San& Chen, Yi Yun& Chen, Wen-Liang. 2016. β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098723
Modern Language Association (MLA)
Tai, Chun San…[et al.]. β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098723
American Medical Association (AMA)
Tai, Chun San& Chen, Yi Yun& Chen, Wen-Liang. β-Lactoglobulin Influences Human Immunity and Promotes Cell Proliferation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098723