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Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats
Joint Authors
Zhuang, Deshu
Ji, Zongshan
Bi, Liangjia
Wang, Xiaochun
Zhou, Qi
Cao, Wenwu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-16
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
This study aims to evaluate the efficacy of hematoporphyrin monomethyl ether- (HMME-) mediated sonodynamic therapy (SDT) on experimental periodontal disease in rats.
Methods.
Periodontal disease was induced by submerging ligatures at the first maxillary molar subgingival region in forty-eight male SD rats.
After 30 days, the ligatures were removed.
The rats were randomly allocated into four groups; the experimental SDT group was treated through hypodermic injection of 40 μg/mL HMME and 3 W/cm2 low-intensity ultrasound irradiation (1 MHz, 600 s).
Those in control groups received 40 μg/mL HMME alone (control 1 group) or 3 W/cm2 ultrasound irradiation alone (control 2 group) or were subjected to neither HMME nor ultrasound (control 3 group).
After 10 days of treatment, all rats were euthanized, the maxilla was obtained for histological examination, and the alveolar bone level was evaluated by histometric analysis.
Results.
The control groups showed more bone loss (P<0.05) after 10 days of treatment than the SDT group.
There is no significant difference among the control groups (P>0.05).
Conclusions.
HMME mediated SDT was an effective therapy of experimental periodontal tissue in rats.
American Psychological Association (APA)
Zhuang, Deshu& Ji, Zongshan& Bi, Liangjia& Wang, Xiaochun& Zhou, Qi& Cao, Wenwu. 2016. Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098732
Modern Language Association (MLA)
Zhuang, Deshu…[et al.]. Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098732
American Medical Association (AMA)
Zhuang, Deshu& Ji, Zongshan& Bi, Liangjia& Wang, Xiaochun& Zhou, Qi& Cao, Wenwu. Low-Intensity Ultrasound Combined with Hematoporphyrin Monomethyl Ether in the Treatment of Experimental Periodontitis in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098732