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Effects of Erythropoietin Administration on Adrenal Glands of LandraceLarge White Pigs after Ventricular Fibrillation
Joint Authors
Faa, Gavino
Pais, Maria Elena
Xanthos, Theodoros
Faa, Armando
Pantazopoulos, Charalampos
Barouxis, Dimitrios
Vasileiou, Panagiotis
Lelovas, Pavlos
Obinu, Eleonora
Locci, Giorgia
Iacovidou, Nicoletta
Papalois, Apostolos E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aim.
To evaluate the effects of erythropoietin administration on the adrenal glands in a swine model of ventricular fibrillation and resuscitation.
Methods.
Ventricular fibrillation was induced via pacing wire forwarded into the right ventricle in 20 female Landrace/Large White pigs, allocated into 2 groups: experimental group treated with bolus dose of erythropoietin (EPO) and control group which received normal saline.
Cardiopulmonary resuscitation (CPR) was performed immediately after drug administration as per the 2010 European Resuscitation Council (ERC) guidelines for Advanced Life Support (ALS) until return of spontaneous circulation (ROSC) or death.
Animals who achieved ROSC were monitored, mechanically ventilated, extubated, observed, and euthanized.
At necroscopy, adrenal glands samples were formalin-fixed, paraffin-embedded, and routinely processed.
Sections were stained with hematoxylin-eosin.
Results.
Oedema and apoptosis were the most frequent histological changes and were detected in all animals in the adrenal cortex and in the medulla.
Mild and focal endothelial lesions were also detected.
A marked interindividual variability in the degree of the intensity of apoptosis and oedema at cortical and medullary level was observed within groups.
Comparing the two groups, higher levels of pathological changes were detected in the control group.
No significant difference between the two groups was observed regarding the endothelial changes.
Conclusions.
In animals exposed to ventricular fibrillation, EPO treatment has protective effects on the adrenal gland.
American Psychological Association (APA)
Faa, Armando& Faa, Gavino& Papalois, Apostolos E.& Obinu, Eleonora& Locci, Giorgia& Pais, Maria Elena…[et al.]. 2016. Effects of Erythropoietin Administration on Adrenal Glands of LandraceLarge White Pigs after Ventricular Fibrillation. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098754
Modern Language Association (MLA)
Faa, Armando…[et al.]. Effects of Erythropoietin Administration on Adrenal Glands of LandraceLarge White Pigs after Ventricular Fibrillation. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098754
American Medical Association (AMA)
Faa, Armando& Faa, Gavino& Papalois, Apostolos E.& Obinu, Eleonora& Locci, Giorgia& Pais, Maria Elena…[et al.]. Effects of Erythropoietin Administration on Adrenal Glands of LandraceLarge White Pigs after Ventricular Fibrillation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098754