Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study
Joint Authors
Siddiqui, Ali Nasir
Khayyam, Khalid Umer
Sharma, Manju
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Despite successful implementation of directly observed treatment, short course (DOTS) in India, the growing number of diabetes mellitus (DM) patients appears to be a cause in the increasing tuberculosis (TB) incidence, affecting their management.
In this regard, a prospective study was conducted on DOTS patients in three primary health care centers in urban slum region of South Delhi, India, to evaluate the effect of DM on sputum conversion, treatment outcome, and adverse drug reactions (ADR) due to anti-TB treatment.
Eligible TB patients underwent blood glucose screening at treatment initiation.
Disease presentation, clinical outcome, and ADRs were compared between patients of TB with and without DM.
Out of 316 patients, the prevalence of DM was found to be 15.8%, in which 19.4% and 9.6% were PTB and EPTB patients, respectively.
DM patients have observed higher sputum positivity (OR 1.247 95% CI; 0.539–2.886) at the end of 2-month treatment and poor outcome (OR 1.176 95% CI; 0.310–4.457) at the completion of treatment compared with non DM patients.
Presence of DM was significantly associated (OR 3.578 95% CI; 1.114–11.494, p = 0.032 ) with the development of ADRs.
DM influences the treatment outcome of PTB patients in our setting and also on the ADR incidence.
American Psychological Association (APA)
Siddiqui, Ali Nasir& Khayyam, Khalid Umer& Sharma, Manju. 2016. Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098757
Modern Language Association (MLA)
Siddiqui, Ali Nasir…[et al.]. Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098757
American Medical Association (AMA)
Siddiqui, Ali Nasir& Khayyam, Khalid Umer& Sharma, Manju. Effect of Diabetes Mellitus on Tuberculosis Treatment Outcome and Adverse Reactions in Patients Receiving Directly Observed Treatment Strategy in India: A Prospective Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098757
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098757