Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis
Joint Authors
Yang, Gui
Fan, Wei
Luo, Baohong
Xu, Zhigao
Wang, Ping
Tang, Shihui
Xu, Peipei
Yu, Mingxia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objectives.
Published data on resistin levels in patients with colorectal cancer (CRC) were conflicting and heterogeneous.
We conducted a meta-analysis of observational studies to examine the association of circulating resistin levels with carcinogenesis of the CRC.
Methods.
Potentially eligible studies published up to November 2015 were searched through MEDLINE, EMBASE, Science Citation Index Expanded database, CNKI, and WanFang database.
The pooled weighted mean differences (WMDs) with 95% confidence intervals (CIs) calculated by fixed- or random-effect model were used to estimate the effects.
Results.
A total of 11 studies involving 965 patients were admitted in our meta-analysis.
The pooled effects indicated that resistin levels were higher in CRC patients compared to healthy controls (WMD: 1.47 ng/mL; 95% CI: 0.78 to 2.16), with significant heterogeneity across the studies ( I 2 = 72 %, p < 0.0001 ).
Subgroup analyses and sensitivity analyses revealed that study quality, design, sample type, and resistin assays may account for this heterogeneity.
No publication bias was observed.
Conclusions.
Our meta-analysis suggests that increased circulating resistin levels are associated with greater risk of colorectal cancer.
Given the limited number of available studies and significant heterogeneity, larger well-designed randomized studies are warranted.
American Psychological Association (APA)
Yang, Gui& Fan, Wei& Luo, Baohong& Xu, Zhigao& Wang, Ping& Tang, Shihui…[et al.]. 2016. Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098774
Modern Language Association (MLA)
Yang, Gui…[et al.]. Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098774
American Medical Association (AMA)
Yang, Gui& Fan, Wei& Luo, Baohong& Xu, Zhigao& Wang, Ping& Tang, Shihui…[et al.]. Circulating Resistin Levels and Risk of Colorectal Cancer: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098774