Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model
Joint Authors
Jiang, Jun
Wei, Jishu
Wu, Junli
Li, Qiang
Jiang, Kuirong
Miao, Yi
Gao, Wentao
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-30
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Hepatic infarcts or abscesses occur after hepatic artery interruption.
We explored the mechanisms of hepatic deprivation-induced acute liver injury and determine whether partial portal vein arterialization attenuated this injury in rats.
Male Sprague-Dawley rats underwent either complete hepatic arterial deprivation or partial portal vein arterialization, or both.
Hepatic ischemia was evaluated using biochemical analysis, light microscopy, and transmission electron microscopy.
Hepatic ATP levels, the expression of hypoxia- and inflammation-associated genes and proteins, and the expression of bile transporter genes were assessed.
Complete dearterialization of the liver induced acute liver injury, as evidenced by the histological changes, significantly increased serum biochemical markers, decreased ATP content, increased expression of hypoxia- and inflammation-associated genes and proteins, and decreased expression of bile transporter genes.
These detrimental changes were extenuated but not fully reversed by partial portal vein arterialization, which also attenuated ductular reaction and fibrosis in completely dearterialized rat livers.
Collectively, complete hepatic deprivation causes severe liver injury, including bile infarcts and biloma formation.
Partial portal vein arterialization seems to protect against acute ischemia-hypoxia-induced liver injury.
American Psychological Association (APA)
Jiang, Jun& Wei, Jishu& Wu, Junli& Gao, Wentao& Li, Qiang& Jiang, Kuirong…[et al.]. 2016. Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098787
Modern Language Association (MLA)
Jiang, Jun…[et al.]. Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098787
American Medical Association (AMA)
Jiang, Jun& Wei, Jishu& Wu, Junli& Gao, Wentao& Li, Qiang& Jiang, Kuirong…[et al.]. Partial Portal Vein Arterialization Attenuates Acute Bile Duct Injury Induced by Hepatic Dearterialization in a Rat Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098787