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MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy
Joint Authors
Staneva, R.
Čukuranović, Rade
Jankovic-Velickovic, Ljubinka
Polenakovic, Momir
Stojnev, Slavica
Popovska-Jankovic, Katerina
Noveski, Predrag
Plaseska-Karanfilska, D.
Stefanovic, Vladisav
Toncheva, D.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Balkan endemic nephropathy (BEN) is a disease that affects people that live in the alluvial plains along the tributaries of the Danube River in the Balkan region.
BEN is a chronic tubulointerstitial disease with a slow progression to terminal renal failure and has strong association with upper tract urothelial carcinoma (UTUC).
There are several hypotheses about the etiology of BEN, but only the toxic effect of aristolochic acid has been confirmed as a risk factor in the occurrence of the disease.
Aberrantly expressed miRNAs have been shown to be associated with many types of cancers.
A number of studies have investigated the expression of microRNAs in urothelial carcinoma, mainly on urothelial bladder cancer, and only a few have included patients with UTUC.
Here we present the first study of microRNA profiling in UTUC tissues from patients with BEN (BEN-UTUC) and patients with UTUC from nonendemic Balkan regions (non-BEN-UTUC) in comparison to normal kidney tissues.
We found 10 miRNAs that were differentially expressed in patients with BEN-UTUC and 15 miRNAs in patients with non-BEN-UTUC.
miRNA signature determined in BEN-UTUC patients differs from the non-BEN-UTUC patients; only miR-205-5p was mutual in both groups.
American Psychological Association (APA)
Popovska-Jankovic, Katerina& Noveski, Predrag& Jankovic-Velickovic, Ljubinka& Stojnev, Slavica& Čukuranović, Rade& Stefanovic, Vladisav…[et al.]. 2016. MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098789
Modern Language Association (MLA)
Popovska-Jankovic, Katerina…[et al.]. MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098789
American Medical Association (AMA)
Popovska-Jankovic, Katerina& Noveski, Predrag& Jankovic-Velickovic, Ljubinka& Stojnev, Slavica& Čukuranović, Rade& Stefanovic, Vladisav…[et al.]. MicroRNA Profiling in Patients with Upper Tract Urothelial Carcinoma Associated with Balkan Endemic Nephropathy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098789
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098789