Immunological Evasion in Glioblastoma
Joint Authors
Sotelo, Julio
Magaña-Maldonado, Roxana
Chávez-Cortez, Elda Georgina
Olascoaga-Arellano, Nora Karen
López-Mejía, Mariana
Maldonado-Leal, Fernando Manuel
Pineda, Benjamín
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glioblastoma is the most aggressive tumor in Central Nervous System in adults.
Among its features, modulation of immune system stands out.
Although immune system is capable of detecting and eliminating tumor cells mainly by cytotoxic T and NK cells, tumor microenvironment suppresses an effective response through recruitment of modulator cells such as regulatory T cells, monocyte-derived suppressor cells, M2 macrophages, and microglia as well as secretion of immunomodulators including IL-6, IL-10, CSF-1, TGF-β, and CCL2.
Other mechanisms that induce immunosuppression include enzymes as indolamine 2,3-dioxygenase.
For this reason it is important to develop new therapies that avoid this immune evasion to promote an effective response against glioblastoma.
American Psychological Association (APA)
Magaña-Maldonado, Roxana& Chávez-Cortez, Elda Georgina& Olascoaga-Arellano, Nora Karen& López-Mejía, Mariana& Maldonado-Leal, Fernando Manuel& Sotelo, Julio…[et al.]. 2016. Immunological Evasion in Glioblastoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098800
Modern Language Association (MLA)
Magaña-Maldonado, Roxana…[et al.]. Immunological Evasion in Glioblastoma. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098800
American Medical Association (AMA)
Magaña-Maldonado, Roxana& Chávez-Cortez, Elda Georgina& Olascoaga-Arellano, Nora Karen& López-Mejía, Mariana& Maldonado-Leal, Fernando Manuel& Sotelo, Julio…[et al.]. Immunological Evasion in Glioblastoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098800
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098800