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Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer
Joint Authors
Wu, Yan
Gu, Yan
Guo, Shanyu
Dai, Qiancheng
Zhang, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
ARID1A is one of the important cancer-related genes and regulates transcription of certain genes by altering chromatin structure.
Inactivated mutations and decreased expression of ARID1A gene have been reported in several kinds of cancer.
Histone H2B is a major component of chromatin and encoded by HIST1H2BE.
The goal of the study is to evaluate expressing status of ARID1A and H2B as well as their correlation on breast cancer.
Gene expression profiles of ARID1A and H2B on Oncomine database are analyzed.
Tissue microarray of breast cancer was used for examination of ARID1A and H2B expression by immunohistochemistry.
As a result, the disagreement of ARID1A expression was found, while HIST1H2BE expression is elevated in 4 out of 5 datasets on Oncomine database.
There were 15 cases (20%) of breast cancers that were positive for ARID1A.
Fifty-eight out of 75 cases of breast cancer (77.3%) were highly expressed for H2B protein and 17 cases (22.7%) were low expressed for H2B protein.
All cases with ARID1A expression are overlapped with H2B high expression.
Among 15 cases with ARID1A and H2B coexpression, 13 are invasive ductal carcinoma and 2 are mucinous carcinoma.
Our results indicate that ARID1A gene may be involved in carcinogenesis of some subtypes of breast cancer.
American Psychological Association (APA)
Wu, Yan& Gu, Yan& Guo, Shanyu& Dai, Qiancheng& Zhang, Wei. 2016. Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098828
Modern Language Association (MLA)
Wu, Yan…[et al.]. Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098828
American Medical Association (AMA)
Wu, Yan& Gu, Yan& Guo, Shanyu& Dai, Qiancheng& Zhang, Wei. Expressing Status and Correlation of ARID1A and Histone H2B on Breast Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098828
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098828