![](/images/graphics-bg.png)
miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma
Joint Authors
Ding, Dong
Zhang, Yaodong
Yang, Renjie
Wang, Xing
Ji, Guwei
Huo, Liqun
Shao, Zicheng
Li, Xiangcheng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aim.
To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells.
Methods.
Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells.
Transfection of HCC cell lines was performed by miR-940 mimics; the abilities of invasion and migration were assessed through Transwell array.
Western blot represents the alteration in expression of CXCR2 by miR-940 mimics.
Results.
miR-940 expression was decreased significantly in the HCC tissues and the relevant cell lines.
miR-940 upregulation suppressed the invasion and migration of HCC cells in vitro.
Furthermore, the CXCR2 was downregulated to suppress invasion and migration after miR-940 mimics.
Moreover, decreased miR-940 expression was negatively correlated with Edmondson grade (P=0.008), tumor microsatellite or multiple tumors (P=0.04), vascular invasion (P=0.035), and recurrence and metastasis (P=0.038).
Kaplan-Meier analysis demonstrated that decreased miR-940 expression contributed to poor overall survival (P<0.05).
Conclusions.
Our findings present that miR-940 acts as a pivotal adaptor of CXCR2 and its transcription downregulated CXCR2 expression to decrease HCC invasion and migration in vitro.
Our study suggests that miR-940 may be a novel poor prognostic biomarker for HCC.
American Psychological Association (APA)
Ding, Dong& Zhang, Yaodong& Yang, Renjie& Wang, Xing& Ji, Guwei& Huo, Liqun…[et al.]. 2016. miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098831
Modern Language Association (MLA)
Ding, Dong…[et al.]. miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098831
American Medical Association (AMA)
Ding, Dong& Zhang, Yaodong& Yang, Renjie& Wang, Xing& Ji, Guwei& Huo, Liqun…[et al.]. miR-940 Suppresses Tumor Cell Invasion and Migration via Regulation of CXCR2 in Hepatocellular Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098831