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Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice
Joint Authors
Li, Fengling
Han, Guosheng
Wu, Kexiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Therapeutic approach for Alzheimer’s disease (AD) is still deficient.
To find active compounds from herbal medicine is of interest in the alleviation of AD symptoms.
This study aimed to investigate the protective effects of Tanshinone IIA (TIIA) on memory performance and synaptic plasticity in a transgenic AD model at the early phase.
25–100 mg/kg TIIA (intraperitoneal injection, i.p.) was administered to the six-month-old APP and PS1 transgenic mice for 30 consecutive days.
After treatment, spatial memory, synaptic plasticity, and related mechanisms were investigated.
Our result showed that memory impairment in AD mice was mitigated by 50 and 100 mg/kg TIIA treatments.
Hippocampal long-term potentiation was impaired in AD model but rescued by 100 mg/kg TIIA treatment.
Mechanically, TIIA treatment reduced the accumulations of beta-amyloid 1–42, C-terminal fragments (CTFs), and p-Tau in the AD model.
TIIA did not affect basal BDNF but promoted depolarization-induced BDNF synthesis in the AD mice.
Taken together, TIIA repairs hippocampal LTP and memory, likely, through facilitating the clearance of AD-related proteins and activating synaptic BDNF synthesis.
TIIA might be a candidate drug for AD treatment.
American Psychological Association (APA)
Li, Fengling& Han, Guosheng& Wu, Kexiang. 2016. Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098836
Modern Language Association (MLA)
Li, Fengling…[et al.]. Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098836
American Medical Association (AMA)
Li, Fengling& Han, Guosheng& Wu, Kexiang. Tanshinone IIA Alleviates the AD Phenotypes in APP and PS1 Transgenic Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098836
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098836