![](/images/graphics-bg.png)
Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection
Joint Authors
Lin, Ping-Ting
Huang, Yi-Chia
Huang, Shih-Chien
Cheng, Shao-Bin
Liu, Hsiao-Tien
Peng, Yi-Shan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Vitamin B-6 has a strong antioxidative effect.
It would be useful to determine whether vitamin B-6 supplementation had effects on antioxidant capacities in patients with hepatocellular carcinoma (HCC) who had recently undergone tumor resection.
Thirty-three HCC patients were randomly assigned to either the placebo (n=16) group or the vitamin B-6 50 mg/d (n=17) group for 12 weeks.
Plasma pyridoxal 5′-phosphate, homocysteine, indicators of oxidative stress, and antioxidant capacities were measured.
Plasma homocysteine in the vitamin B-6 group was significantly decreased at week 12, while the level of trolox equivalent antioxidant capacity (TEAC) was significantly increased at the end of the intervention period.
Vitamin B-6 supplementation had a significant reducing effect on the change of plasma homocysteine (β=-2.4, p=0.02) but not on the change of TEAC level after adjusting for potential confounders.
The change of plasma homocysteine was significantly associated with the change of TEAC after adjusting for potential confounders (β=-162.0, p=0.03).
Vitamin B-6 supplementation seemed to mediate antioxidant capacity via reducing plasma homocysteine rather than having a direct antioxidative effect in HCC patients who had recently undergone tumor resection.
The clinical trial number is NCT01964001, ClinicalTrials.gov.
American Psychological Association (APA)
Cheng, Shao-Bin& Lin, Ping-Ting& Liu, Hsiao-Tien& Peng, Yi-Shan& Huang, Shih-Chien& Huang, Yi-Chia. 2016. Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098845
Modern Language Association (MLA)
Cheng, Shao-Bin…[et al.]. Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098845
American Medical Association (AMA)
Cheng, Shao-Bin& Lin, Ping-Ting& Liu, Hsiao-Tien& Peng, Yi-Shan& Huang, Shih-Chien& Huang, Yi-Chia. Vitamin B-6 Supplementation Could Mediate Antioxidant Capacity by Reducing Plasma Homocysteine Concentration in Patients with Hepatocellular Carcinoma after Tumor Resection. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098845