Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model
Joint Authors
Sun, Yu
Wang, Kexin
Fernandez-Escobar, Alejandro
Han, Shuhong
Zhu, Ping
Wang, Jun-Hui
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer’s disease (AD) has been described in the literature, to be associated with impairment of executive function which develops early in the course of disease, and an effective treatment for this clinical feature remains elusive.
Preclinical studies have implied that lamotrigine, an antiepileptic agent, could be a potential treatment for executive dysfunction in AD patients.
Although there have been promising results in previous studies with lamotrigine, executive function has never been measured using animal models.
The aim of the present study was to evaluate the effects of lamotrigine on executive function and determine whether lamotrigine can attenuate inflammatory response in an AD mouse model.
Nontransgenic and transgenic mice were treated with lamotrigine (0 or 30 mg/kg/day) in a standard laboratory chow diet starting at 3 months of age.
After 6 months of continuous lamotrigine administration, there was a marked improvement in executive function and a significant attenuation in the expression of proinflammatory cytokines.
These results suggest that lamotrigine could ameliorate executive dysfunction and brain inflammatory response in the mouse model of AD and early lamotrigine intervention may be a promising therapeutic strategy for AD.
American Psychological Association (APA)
Wang, Kexin& Fernandez-Escobar, Alejandro& Han, Shuhong& Zhu, Ping& Wang, Jun-Hui& Sun, Yu. 2016. Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098852
Modern Language Association (MLA)
Wang, Kexin…[et al.]. Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098852
American Medical Association (AMA)
Wang, Kexin& Fernandez-Escobar, Alejandro& Han, Shuhong& Zhu, Ping& Wang, Jun-Hui& Sun, Yu. Lamotrigine Reduces Inflammatory Response and Ameliorates Executive Function Deterioration in an Alzheimer’s-Like Mouse Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098852
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098852