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Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma
Joint Authors
Aralica, Merica
Štifter, Sanja
Valković, Toni
Lučin, Ksenija
Jonjić, Nives
Seili-Bekafigo, Irena
Duletić-Načinović, Antica
Babarović, Emina
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this pilot study was to determine the plasma levels of monocyte chemotactic protein-1 (MCP-1) and possible associations with angiogenesis and the main clinical features of untreated patients with multiple myeloma (MM).
ELISA was used to determine plasma MCP-1 levels in 45 newly diagnosed MM patients and 24 healthy controls.
The blood vessels were highlighted by immunohistochemical staining, and computer-assisted image analysis was used for more objective and accurate determination of two parameters of angiogenesis: microvessel density (MVD) and total vascular area (TVA).
The plasma levels of MCP-1 were compared to these parameters and the presence of anemia, renal dysfunction, and bone lesions.
A significant positive correlation was found between plasma MCP-1 concentrations and TVA ( p = 0.02 ).
The MCP-1 levels were significantly higher in MM patients with evident bone lesions ( p = 0.01 ), renal dysfunction ( p = 0.02 ), or anemia ( p = 0.04 ).
Therefore, our preliminary results found a positive association between plasma MCP-1 levels, angiogenesis (expressed as TVA), and clinical features in patients with MM.
However, additional prospective studies with a respectable number of patients should be performed to authenticate these results and establish MCP-1 as a possible target of active treatment.
American Psychological Association (APA)
Valković, Toni& Babarović, Emina& Lučin, Ksenija& Štifter, Sanja& Aralica, Merica& Seili-Bekafigo, Irena…[et al.]. 2016. Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098873
Modern Language Association (MLA)
Valković, Toni…[et al.]. Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098873
American Medical Association (AMA)
Valković, Toni& Babarović, Emina& Lučin, Ksenija& Štifter, Sanja& Aralica, Merica& Seili-Bekafigo, Irena…[et al.]. Plasma Levels of Monocyte Chemotactic Protein-1 Are Associated with Clinical Features and Angiogenesis in Patients with Multiple Myeloma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098873
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098873