Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the AktGSK3β Signaling Pathway
Joint Authors
Tao, Guorong
Luo, Yan
Xue, Qingsheng
Li, Guohui
Yu, Buwei
Xia, Yimeng
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Demand is increasing for safer inhalational anesthetics for use in pediatric anesthesia.
In this regard, researchers have debated whether isoflurane is more toxic to the developing brain than desflurane.
In the present study, we compared the effects of postnatal exposure to isoflurane with those of desflurane on long-term cognitive performance and investigated the role of the Akt/GSK3β signaling pathway.
Postnatal day 6 (P6) mice were exposed to either isoflurane or desflurane, after which the phosphorylation levels of Akt/GSK3β and learning and memory were assessed at P8 or P31.
The phosphorylation levels of Akt/GSK3β and learning and memory were examined after intervention with lithium.
We found that isoflurane, but not desflurane, impaired spatial learning and memory at P31.
Accompanied by behavioral change, only isoflurane decreased p-Akt (ser473) and p-GSK3β (ser9) expressions, which led to GSK3β overactivation.
Lithium prevented GSK3β overactivation and alleviated isoflurane-induced cognitive deficits.
These results suggest that isoflurane is more likely to induce developmental neurotoxicity than desflurane in context of multiple exposures and that the Akt/GSK3β signaling pathway partly participates in this process.
GSK3β inhibition might be an effective way to protect against developmental neurotoxicity.
American Psychological Association (APA)
Tao, Guorong& Xue, Qingsheng& Luo, Yan& Li, Guohui& Xia, Yimeng& Yu, Buwei. 2016. Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the AktGSK3β Signaling Pathway. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098885
Modern Language Association (MLA)
Tao, Guorong…[et al.]. Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the AktGSK3β Signaling Pathway. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098885
American Medical Association (AMA)
Tao, Guorong& Xue, Qingsheng& Luo, Yan& Li, Guohui& Xia, Yimeng& Yu, Buwei. Isoflurane Is More Deleterious to Developing Brain Than Desflurane: The Role of the AktGSK3β Signaling Pathway. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098885