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NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis
Joint Authors
Cancino-Díaz, Mario E.
Hernández-Rivera, Mirsha Pamela
Ramírez-Ramírez, Alicia
Chiñas-Pérez, Adelaido
Hernández-Montes, Omar
Monroy-Ostria, Amalia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cutaneous leishmaniasis (CL) is endemic in Campeche state, Mexico.
Host and parasite factors are involved in the establishment and development of CL.
Host factors include immune response and genetic background.
NRAMP1 (Natural Resistance Associated Macrophage Protein 1) is important in innate immunity.
Polymorphisms in NRAMP1 have been associated with susceptibility or resistance to infectious and autoimmune diseases.
To study the association of NRAMP1 mutations with CL in patients from Calakmul, Campeche, samples from 115 CL patients and 69 samples of healthy people from the same area were evaluated.
Five regions in NRAMP1 were amplified and digested, looking for mutations in the promoter region (−524G/C), exon 3 (274C/T), exon 8 (823 C7T), and exon 15 (G/A) and deletion of 4 bp in the 3′UTR region.
We found a statistical association between polymorphisms in 3′UTR region and exon 8 and CL [χ2=13.26; p<0.05; OR = 17.00; IC of 95% (2.24–128.99)].
Some patients who needed more than 40 doses of Glucantime® to heal injuries presented mutations in exons 3, 8, and 15.
Multiple or ear lesions were not associated with NRAMP1 polymorphism.
American Psychological Association (APA)
Hernández-Rivera, Mirsha Pamela& Ramírez-Ramírez, Alicia& Chiñas-Pérez, Adelaido& Monroy-Ostria, Amalia& Cancino-Díaz, Mario E.& Hernández-Montes, Omar. 2016. NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098893
Modern Language Association (MLA)
Hernández-Rivera, Mirsha Pamela…[et al.]. NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098893
American Medical Association (AMA)
Hernández-Rivera, Mirsha Pamela& Ramírez-Ramírez, Alicia& Chiñas-Pérez, Adelaido& Monroy-Ostria, Amalia& Cancino-Díaz, Mario E.& Hernández-Montes, Omar. NRAMP1 Polymorphisms like Susceptibility Marker in Mexican Focus of Cutaneous Leishmaniasis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098893