The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy
Joint Authors
Abe, Yoshinori
Tanaka, Nobuyuki
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-26
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Lung cancer is the most common cause of cancer-related death worldwide and is classified into small cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC).
Several gene mutations that contribute to aberrant cell proliferation have been identified in lung adenocarcinoma, a part of NSCLC.
Various anticancer drugs that target these mutated molecules have been developed for NSCLC treatment.
However, although molecularly targeted drugs are initially effective for patients, the 5-year survival rate remains low because of tumor relapse.
Therefore, more effective drugs for lung cancer treatment should be developed.
The hedgehog (HH) signaling pathway contributes to organ development and stem cell maintenance, and aberrant activation of this signaling pathway is observed in various cancers including lung cancer.
In lung cancer, HH signaling pathway upregulates cancer cell proliferation and maintains cancer stem cells as well as cancer-associated fibroblasts (CAFs).
Furthermore, physical contact between CAFs and NSCLC cells induces HH signaling pathway activation in NSCLC cells to enhance their metastatic potential.
Therefore, HH signaling pathway inhibitors could be a useful option for lung cancer therapy.
American Psychological Association (APA)
Abe, Yoshinori& Tanaka, Nobuyuki. 2016. The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098896
Modern Language Association (MLA)
Abe, Yoshinori& Tanaka, Nobuyuki. The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098896
American Medical Association (AMA)
Abe, Yoshinori& Tanaka, Nobuyuki. The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098896