The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model
Joint Authors
Gariglio, Patricio
Damian-Morales, Gabriela
Serafín-Higuera, Nicolás
Cortés-Malagón, Enoc M.
Bonilla-Delgado, José
Rodríguez-Uribe, Genaro
Ocadiz-Delgado, Rodolfo
Lambert, Paul F.
Moreno-Eutimio, Mario Adan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
The aim of this study was to analyze the effects of the HPV16 E7 oncoprotein on dendritic cells (DCs) and CD11b+Gr1+ cells using the K14E7 transgenic mouse model.
Materials and Methods.
The morphology of DCs was analyzed in male mouse skin on epidermal sheets using immunofluorescence and confocal microscopy.
Flow cytometry was used to determine the percentages of DCs and CD11b+Gr1+ cells in different tissues and to evaluate the migration of DCs.
Results.
In the K14E7 mouse model, the morphology of Langerhans cells and the migratory activity of dendritic cells were abnormal.
An increase in CD11b+Gr1+ cells was observed in the blood and skin of K14E7 mice, and molecules related to CD11b+Gr1+ chemoattraction (MCP1 and S100A9) were upregulated.
Conclusions.
These data suggest that the HPV16 E7 oncoprotein impairs the function and morphology of DCs and induces the systemic accumulation of CD11b+Gr1+ cells.
American Psychological Association (APA)
Damian-Morales, Gabriela& Serafín-Higuera, Nicolás& Moreno-Eutimio, Mario Adan& Cortés-Malagón, Enoc M.& Bonilla-Delgado, José& Rodríguez-Uribe, Genaro…[et al.]. 2016. The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098975
Modern Language Association (MLA)
Damian-Morales, Gabriela…[et al.]. The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098975
American Medical Association (AMA)
Damian-Morales, Gabriela& Serafín-Higuera, Nicolás& Moreno-Eutimio, Mario Adan& Cortés-Malagón, Enoc M.& Bonilla-Delgado, José& Rodríguez-Uribe, Genaro…[et al.]. The HPV16 E7 Oncoprotein Disrupts Dendritic Cell Function and Induces the Systemic Expansion of CD11b+Gr1+ Cells in a Transgenic Mouse Model. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098975
