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Involvement of the Nonneuronal Cholinergic System in Bone Remodeling in Rat Midpalatal Suture after Rapid Maxillary Expansion
Joint Authors
Che, Xiaoxia
Guo, Jie
Wang, Lue
Miao, Cong
Ge, Lihua
Tian, Zhenchuan
Wang, Jianhong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Few studies sought to analyze the expression and function of the nonneuronal acetylcholine system in bone remodeling in vivo due to the lack of suitable models.
We established a rat maxilla expansion model in which the midline palatine suture of the rat was rapidly expanded under mechanical force application, inducing tissue remodeling and new bone formation, which could be a suitable model to investigate the role of the nonneuronal acetylcholine system in bone remodeling in vivo.
During the expansion, the expression pattern changes of the nonneuronal cholinergic system components and the mRNA levels of OPG/RANKL were detected by immunohistochemistry or real-time PCR.
The value of the RANKL/OPG ratio significantly increased after 1 day of expansion, indicating dominant bone resorption induced by the mechanical stimulation; however after 3 days of expansion, the value of the RANKL/OPG ratio significantly decreased, suggesting a dominant role of the subsequent bone formation process.
Increasing expression of Ach was detected after 3 days of expansion which indicated that ACh might play a role in bone formation.
The mRNA expression levels of other components also showed observable changes during the expansion which confirmed the involvement of the nonneuronal cholinergic system in the process of bone remodeling in vivo.
Further researches are still needed to figure out the detailed functions of the nonneuronal cholinergic system and its components.
American Psychological Association (APA)
Che, Xiaoxia& Guo, Jie& Wang, Lue& Miao, Cong& Ge, Lihua& Tian, Zhenchuan…[et al.]. 2016. Involvement of the Nonneuronal Cholinergic System in Bone Remodeling in Rat Midpalatal Suture after Rapid Maxillary Expansion. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098977
Modern Language Association (MLA)
Che, Xiaoxia…[et al.]. Involvement of the Nonneuronal Cholinergic System in Bone Remodeling in Rat Midpalatal Suture after Rapid Maxillary Expansion. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098977
American Medical Association (AMA)
Che, Xiaoxia& Guo, Jie& Wang, Lue& Miao, Cong& Ge, Lihua& Tian, Zhenchuan…[et al.]. Involvement of the Nonneuronal Cholinergic System in Bone Remodeling in Rat Midpalatal Suture after Rapid Maxillary Expansion. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098977
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1098977