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Bone Healing Improvements Using Hyaluronic Acid and HydroxyapatiteBeta-Tricalcium Phosphate in Combination: An Animal Study
Joint Authors
Lin, Che-Tong
Huang, Haw-Ming
Feng, Sheng-Wei
Huang, Yu-Chih
Chang, Yen-Lan
Lo, Yi-June
Tsai, Hsin-Yuan
Fan, Kan-Hsin
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to investigate whether the use of HLA as an aqueous binder of hydroxyapatite/beta-tricalcium phosphate (HA-βTCP) particles can reduce the amount of bone graft needed and increase ease of handling in clinical situations.
In this study, HA/βTCP was loaded in commercially available crosslinking HLA to form a novel HLA/HA-βTCP composite.
Six New Zealand White rabbits (3.0–3.6 kg) were used as test subjects.
Four 6 mm defects were prepared in the parietal bone.
The defects were filled with the HLA/HA-βTCP composite as well as HA-βTCP particle alone.
New bone formation was analyzed by micro-CT and histomorphometry.
Our results indicated that even when the HA-βTCP particle numbers were reduced, the regenerative effect on bone remained when the HLA existed.
The bone volume density (BV/TV ratio) of HLA/HA-βTCP samples was 1.7 times larger than that of the control sample at week 2.
The new bone increasing ratio (NBIR) of HLA/HA-βTCP samples was 1.78 times higher than the control group at week 2.
In conclusion, HA-βTCP powder with HLA contributed to bone healing in rabbit calvarial bone defects.
The addition of HLA to bone grafts not only promoted osteoconduction but also improved handling characteristics in clinical situations.
American Psychological Association (APA)
Chang, Yen-Lan& Lo, Yi-June& Feng, Sheng-Wei& Huang, Yu-Chih& Tsai, Hsin-Yuan& Lin, Che-Tong…[et al.]. 2016. Bone Healing Improvements Using Hyaluronic Acid and HydroxyapatiteBeta-Tricalcium Phosphate in Combination: An Animal Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099023
Modern Language Association (MLA)
Chang, Yen-Lan…[et al.]. Bone Healing Improvements Using Hyaluronic Acid and HydroxyapatiteBeta-Tricalcium Phosphate in Combination: An Animal Study. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099023
American Medical Association (AMA)
Chang, Yen-Lan& Lo, Yi-June& Feng, Sheng-Wei& Huang, Yu-Chih& Tsai, Hsin-Yuan& Lin, Che-Tong…[et al.]. Bone Healing Improvements Using Hyaluronic Acid and HydroxyapatiteBeta-Tricalcium Phosphate in Combination: An Animal Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099023
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099023