Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors
Joint Authors
Schumacher, Justin D.
Guo, Grace L.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Fibroblast growth factors (FGFs) are a family of growth factors critically involved in developmental, physiological, and pathological processes, including embryogenesis, angiogenesis, wound healing, and endocrine functions.
In the liver, several FGFs are produced basally by hepatocytes and hepatic stellate cells (HSCs).
Upon insult to the liver, expression of FGFs in HSCs is greatly upregulated, stimulating hepatocyte regeneration and growth.
Various FGF isoforms have also been shown to directly induce HSC proliferation and activation thereby enabling autocrine and paracrine regulation of HSC function.
Regulation of HSCs by the endocrine FGFs, namely, FGF15/19 and FGF21, has also recently been identified.
With the ability to modulate HSC proliferation and transdifferentiation, targeting FGF signaling pathways constitutes a promising new therapeutic strategy to treat hepatic fibrosis.
American Psychological Association (APA)
Schumacher, Justin D.& Guo, Grace L.. 2016. Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099030
Modern Language Association (MLA)
Schumacher, Justin D.& Guo, Grace L.. Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099030
American Medical Association (AMA)
Schumacher, Justin D.& Guo, Grace L.. Regulation of Hepatic Stellate Cells and Fibrogenesis by Fibroblast Growth Factors. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099030
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099030