The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study
Joint Authors
Grignolo, Federico M.
Fea, Antonio M.
Aragno, Vittoria
Testa, Valeria
Machetta, Federica
Parisi, Simone
D’Antico, Sergio
Spinetta, Roberta
Fusaro, Enrico
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
To determine the effectiveness of autologous platelet lysate (APL) eye drops in patients with primary Sjögren syndrome (SS) dry eye, refractory to standard therapy, in comparison with patients treated with artificial tears.
We focused on the effect of APL on cornea morphology with the in vivo confocal microscopy (IVCM).
Methods.
Patients were assigned to two groups: group A used autologous platelet lysate QID, and group B used preservative-free artificial tears QID, for 90 days.
Ophthalmological assessments included ocular surface disease index (OSDI), best corrected visual acuity (BCVA), Schirmer test, fluorescein score, and breakup time (BUT).
A subgroup of patients in group A underwent IVCM: corneal basal epithelium, subbasal nerves, Langerhans cells, anterior stroma activated keratocytes, and reflectivity were evaluated.
Results.
60 eyes of 30 patients were enrolled; in group A ( n = 20 patients) mean OSDI, fluorescein score, and BUT showed significant improvement compared with group B ( n = 10 patients).
The IVCM showed a significant increase in basal epithelium cells density and subbasal nerve plexus density and number and a decrease in Langerhans cells density ( p < 0.05 ).
Conclusion.
APL was found effective in the treatment of SS dry eye.
IVCM seems to be a useful tool to visualize cornea morphologic modifications.
American Psychological Association (APA)
Fea, Antonio M.& Aragno, Vittoria& Testa, Valeria& Machetta, Federica& Parisi, Simone& D’Antico, Sergio…[et al.]. 2016. The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099048
Modern Language Association (MLA)
Fea, Antonio M.…[et al.]. The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099048
American Medical Association (AMA)
Fea, Antonio M.& Aragno, Vittoria& Testa, Valeria& Machetta, Federica& Parisi, Simone& D’Antico, Sergio…[et al.]. The Effect of Autologous Platelet Lysate Eye Drops: An In Vivo Confocal Microscopy Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099048