N-11C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with 13N-Ammonia PET
Joint Authors
Zhou, Weina
Wang, Xiangcheng
He, Yulin
Nie, Yongzhen
Zhang, Guojian
Wang, Cheng
Wang, Chunmei
Wang, Xuemei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
Using a swine model of acute myocardial ischemia, we sought to validate N-11C-methyl-dopamine (11C-MDA) as an agent capable of imaging cardiac sympathetic nerve injury.
Methods.
Acute myocardial ischemia was surgically generated in Chinese minipigs.
ECG and serum enzyme levels were used to detect the presence of myocardial ischemia.
Paired 11C-MDA PET and 13N-ammonia PET scans were performed at baseline, 1 day, and 1, 3, and 6 months after surgery to relate cardiac sympathetic nerve injury to blood perfusion.
Results.
Seven survived the surgical procedure.
The ECG-ST segment was depressed, and levels of the serum enzymes increased.
Cardiac uptake of tracer was quantified as the defect volume.
Both before and immediately after surgery, the images obtained with 11C-MDA and 13N-ammonia were similar.
At 1 to 6 months after surgery, however, 11C-MDA postsurgical left ventricular myocardial defect volume was significantly greater compared to 13N-ammonia.
Conclusions.
In the Chinese minipig model of acute myocardial ischemia, the extent of the myocardial defect as visualized by 11C-MDA is much greater than would be suggested by blood perfusion images, and the recovery from myocardial sympathetic nerve injury is much slower than the restoration of blood perfusion.
11C-MDA PET may provide additional biological information during recovery from ischemic heart disease.
American Psychological Association (APA)
Zhou, Weina& Wang, Xiangcheng& He, Yulin& Nie, Yongzhen& Zhang, Guojian& Wang, Cheng…[et al.]. 2016. N-11C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with 13N-Ammonia PET. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099054
Modern Language Association (MLA)
Zhou, Weina…[et al.]. N-11C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with 13N-Ammonia PET. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099054
American Medical Association (AMA)
Zhou, Weina& Wang, Xiangcheng& He, Yulin& Nie, Yongzhen& Zhang, Guojian& Wang, Cheng…[et al.]. N-11C-Methyl-Dopamine PET Imaging of Sympathetic Nerve Injury in a Swine Model of Acute Myocardial Ischemia: A Comparison with 13N-Ammonia PET. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099054