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Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers
Joint Authors
Cha, Jung-Joon
Park, Yangkyu
Yun, Joho
Kim, Hyeon Woo
Park, Chang-Ju
Kang, Giseok
Jung, Minhyun
Pak, Boryeong
Jin, Suk-Won
Lee, Jong-Hyun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Senescence of cardiac myocytes is frequently associated with heart diseases.
To analyze senescence in cardiac myocytes, a number of biomarkers have been isolated.
However, due to the complex nature of senescence, multiple markers are required for a single assay to accurately depict complex physiological changes associated with senescence.
In single cells, changes in both cytoplasm and cell membrane during senescence can affect the changes in electrical impedance.
Based on this phenomenon, we developed MEDoS, a novel microelectrochemical impedance spectroscopy for diagnosis of senescence, which allows us to precisely measure quantitative changes in electrical properties of aging cells.
Using cardiac myocytes isolated from 3-, 6-, and 18-month-old isogenic zebrafish, we examined the efficacy of MEDoS and showed that MEDoS can identify discernible changes in electrical impedance.
Taken together, our data demonstrated that electrical impedance in cells at different ages is distinct with quantitative values; these results were comparable with previously reported ones.
Therefore, we propose that MEDoS be used as a new biomarker-independent methodology to obtain quantitative data on the biological senescence status of individual cells.
American Psychological Association (APA)
Cha, Jung-Joon& Park, Yangkyu& Yun, Joho& Kim, Hyeon Woo& Park, Chang-Ju& Kang, Giseok…[et al.]. 2016. Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099068
Modern Language Association (MLA)
Cha, Jung-Joon…[et al.]. Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099068
American Medical Association (AMA)
Cha, Jung-Joon& Park, Yangkyu& Yun, Joho& Kim, Hyeon Woo& Park, Chang-Ju& Kang, Giseok…[et al.]. Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099068