Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus
Joint Authors
Morán-Santibañez, Karla
Cruz-Suárez, Lucia Elizabeth
Ricque-Marie, Denis
Robledo, Daniel
Freile-Pelegrín, Yolanda
Peña-Hernández, Mario A.
Rodríguez-Padilla, Cristina
Trejo-Avila, Laura M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Sulfated polysaccharides (SPs) extracted from five seaweed samples collected or cultivated in Mexico (Macrocystis pyrifera, Eisenia arborea, Pelvetia compressa, Ulva intestinalis, and Solieria filiformis) were tested in this study in order to evaluate their effect on measles virus in vitro.
All polysaccharides showed antiviral activity (as measured by the reduction of syncytia formation) and low cytotoxicity (MTT assay) at inhibitory concentrations.
SPs from Eisenia arborea and Solieria filiformis showed the highest antiviral activities (confirmed by qPCR) and were selected to determine their combined effect.
Their synergistic effect was observed at low concentrations (0.0274 μg/mL and 0.011 μg/mL of E.
arborea and S.
filiformis SPs, resp.), which exhibited by far a higher inhibitory effect (96% syncytia reduction) in comparison to the individual SP effects (50% inhibition with 0.275 μg/mL and 0.985 μg/mL of E.
arborea and S.
filiformis, resp.).
Time of addition experiments and viral penetration assays suggest that best activities of these SPs occur at different stages of infection.
The synergistic effect would allow reducing the treatment dose and toxicity and minimizing or delaying the induction of antiviral resistance; sulfated polysaccharides of the tested seaweed species thus appear as promising candidates for the development of natural antiviral agents.
American Psychological Association (APA)
Morán-Santibañez, Karla& Cruz-Suárez, Lucia Elizabeth& Ricque-Marie, Denis& Robledo, Daniel& Freile-Pelegrín, Yolanda& Peña-Hernández, Mario A.…[et al.]. 2016. Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099074
Modern Language Association (MLA)
Morán-Santibañez, Karla…[et al.]. Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1099074
American Medical Association (AMA)
Morán-Santibañez, Karla& Cruz-Suárez, Lucia Elizabeth& Ricque-Marie, Denis& Robledo, Daniel& Freile-Pelegrín, Yolanda& Peña-Hernández, Mario A.…[et al.]. Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099074