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Comparison and Prognostic Analysis of Adjuvant Radiotherapy versus Salvage Radiotherapy for Treatment of Radically Resected Locally Advanced Esophageal Squamous Cell Carcinoma
Joint Authors
Xu, Xin
Xie, Hua-Ying
Zhou, Di
Huang, Ren-Hua
Bai, Yong-Rui
Yuan, Jun
Ye, Ming
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To compare adjuvant radiotherapy and salvage radiotherapy after radical resection for treatment of esophageal squamous cell carcinoma (ESCC).
Methods.
Data from 155 patients with locally advanced ESCC who underwent radical resection and received postoperative radiotherapy from 2005 to 2011 were reviewed.
Seventy-nine patients received adjuvant radiotherapy and 76 received salvage radiotherapy after locoregional recurrence.
Results.
The median disease-free survival (DFS) and overall survival (OS) were significantly higher in the adjuvant radiotherapy group than the salvage radiotherapy group (DFS 25.73 months versus 10.73 months, P < 0.001 ; OS 33.33 months versus 26.22 months, P = 0.006 ).
The independent prognostic factors for DFS were performance status (PS) before radiotherapy and pathological stage in the adjuvant radiotherapy group, compared with lymph node metastasis, tumor location, and adjuvant chemotherapy in the salvage radiotherapy group.
The independent prognostic factors for OS were age and PS in both groups.
No differences in median DFS and OS between the groups were observed in patients aged > 65 years or with PS ≥ 2.
Conclusion.
Compared to salvage radiotherapy, postoperative adjuvant radiotherapy can prolong DFS and OS for patients with radically resected local advanced ESCC but cannot improve survival for patients aged > 65 years or with PS ≥ 2.
American Psychological Association (APA)
Xu, Xin& Xie, Hua-Ying& Zhou, Di& Huang, Ren-Hua& Bai, Yong-Rui& Yuan, Jun…[et al.]. 2016. Comparison and Prognostic Analysis of Adjuvant Radiotherapy versus Salvage Radiotherapy for Treatment of Radically Resected Locally Advanced Esophageal Squamous Cell Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099083
Modern Language Association (MLA)
Xu, Xin…[et al.]. Comparison and Prognostic Analysis of Adjuvant Radiotherapy versus Salvage Radiotherapy for Treatment of Radically Resected Locally Advanced Esophageal Squamous Cell Carcinoma. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099083
American Medical Association (AMA)
Xu, Xin& Xie, Hua-Ying& Zhou, Di& Huang, Ren-Hua& Bai, Yong-Rui& Yuan, Jun…[et al.]. Comparison and Prognostic Analysis of Adjuvant Radiotherapy versus Salvage Radiotherapy for Treatment of Radically Resected Locally Advanced Esophageal Squamous Cell Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099083