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Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?
Joint Authors
Richtzenhain, L. J.
Asano, Karen M.
Hora, Aline S.
Tonietti, Paloma de Oliveira
Brandao, Paulo E.
Maiorka, Paulo
Taniwaki, S. A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections.
Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies.
In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a–c, E, and M genes were sequenced from samples obtained from cats with or without FIP.
All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way.
In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account.
American Psychological Association (APA)
Hora, Aline S.& Tonietti, Paloma de Oliveira& Taniwaki, S. A.& Asano, Karen M.& Maiorka, Paulo& Richtzenhain, L. J.…[et al.]. 2016. Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099086
Modern Language Association (MLA)
Hora, Aline S.…[et al.]. Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099086
American Medical Association (AMA)
Hora, Aline S.& Tonietti, Paloma de Oliveira& Taniwaki, S. A.& Asano, Karen M.& Maiorka, Paulo& Richtzenhain, L. J.…[et al.]. Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099086
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099086