Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma
Joint Authors
Xu, Yi
Lin, Yun-Peng
Yang, Dong
Zhang, Geng
Zhou, Hui-Fang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
MicroRNAs (miRNAs) play critical roles in the progression of laryngeal cancer (LC).
In this study, we aimed to investigate whether miR-149 is associated with the prognosis of patients with LC.
A total of 97 laryngeal squamous cell carcinoma patients who underwent tumor resection were included in our follow-up study.
In vitro studies was performed in cancer cell line Hep-2 to explore the antitumor role of miR-149 in LC.
We found that the expression of miR-149 was significantly lower in tumor tissues, compared with vocal cord polyp tissues ( P < 0.05 ).
Kaplan-Meier analysis revealed that miR-149 expression status is significantly associated with survival duration (log rank test, P < 0.0 5 ), and multivariate Cox regression analysis revealed that patients with low miR-149 expression had shorter survival times compared with patients with high miR-149 expression.
In vitro studies revealed that the exogenous expression of miRNA-149 inhibits the proliferation of human Hep-2 cells and induces cell apoptosis.
Our study suggests that miR-149 expression in laryngeal squamous cell carcinoma tissues is critically associated with the prognosis of patients, and the ectopic expression of miR-149 in Hep-2 cells inhibits proliferation and cell cycle progression.
American Psychological Association (APA)
Xu, Yi& Lin, Yun-Peng& Yang, Dong& Zhang, Geng& Zhou, Hui-Fang. 2016. Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099087
Modern Language Association (MLA)
Xu, Yi…[et al.]. Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099087
American Medical Association (AMA)
Xu, Yi& Lin, Yun-Peng& Yang, Dong& Zhang, Geng& Zhou, Hui-Fang. Clinical Significance of miR-149 in the Survival of Patients with Laryngeal Squamous Cell Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099087
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099087