Renal IschemiaReperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning
Joint Authors
Guneli, Ensari
Ozbilgin, Sule
Boztas, Nilay
Ozbilgin, Mucahit
Derici, Serhan
Meseri, Reci
Ergur, Bekir Ugur
Akan, Mert
Ozkardesler, Sevda
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The aim of this study was to evaluate the effects of local ischemic preconditioning using biochemical markers and histopathologically in the diabetic rat renal IR injury model.
Methods.
DM was induced using streptozotocin.
Rats were divided into four groups: Group I, nondiabetic sham group ( n = 7 ), Group II, diabetic sham group ( n = 6 ), Group III, diabetic IR group (diabetic IR group, n = 6 ), and Group IV, diabetic IR + local ischemic preconditioning group (diabetic IR + LIPC group, n = 6 ).
Ischemic renal injury was induced by clamping the bilateral renal artery for 45 min.
4 h following ischemia, clearance protocols were applied to assess biochemical markers and histopathologically in rat kidneys.
Results.
The histomorphologic total cell injury scores of the nondiabetic sham group were significantly lower than diabetic sham, diabetic IR, and diabetic IR + LIPC groups.
Diabetic IR group scores were not significantly different than the diabetic sham group.
But diabetic IR + LIPC group scores were significantly higher than the diabetic sham and diabetic IR groups.
Conclusion.
Local ischemic preconditioning does not reduce the risk of renal injury induced by ischemia/reperfusion in diabetic rat model.
American Psychological Association (APA)
Ozbilgin, Sule& Ozkardesler, Sevda& Akan, Mert& Boztas, Nilay& Ozbilgin, Mucahit& Ergur, Bekir Ugur…[et al.]. 2016. Renal IschemiaReperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099092
Modern Language Association (MLA)
Ozbilgin, Sule…[et al.]. Renal IschemiaReperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099092
American Medical Association (AMA)
Ozbilgin, Sule& Ozkardesler, Sevda& Akan, Mert& Boztas, Nilay& Ozbilgin, Mucahit& Ergur, Bekir Ugur…[et al.]. Renal IschemiaReperfusion Injury in Diabetic Rats: The Role of Local Ischemic Preconditioning. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099092