In Vitro Bioactivity Study of RGD-Coated Titanium Alloy Prothesis for Revision Total Hip Arthroplasty

Joint Authors

Man, Zhentao
Sha, Dan
Sun, Shui
Li, Tao
Li, Bin
Yang, Guang
Zhang, Laibo
Wu, Changshun
Jiang, Peng
Han, Xiaojuan
Li, Wei

Source

BioMed Research International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-07-14

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Medicine

Abstract EN

Total hip arthroplasty (THA) is a common procedure for the treatment of end-stage hip joint disease, and the demand for revision THA will double by 2026.

Ti6Al4V (Titanium, 6% Aluminum, and 4% Vanadium) is a kind of alloy commonly used to make hip prothesis.

To promote the osseointegration between the prothesis and host bone is very important for the revision THA.

The peptide Arg-Gly-Asp (RGD) could increase cell attachment and has been used in the vascular tissue engineering.

In this study, we combined the RGD with Ti6Al4V alloy using the covalent cross-linking method to fabricate the functional Ti6Al4V alloy (FTA).

The distribution of RGD oligopeptide on the FTA was even and homogeneous.

The FTA scaffolds could promote mouse osteoblasts adhesion and spreading.

Furthermore, the result of RT-qPCR indicated that the FTA scaffolds were more beneficial to osteogenesis, which may be due to the improvement of osteoblast adhesion by the RGD oligopeptide coated on FTA.

Overall, the FTA scaffolds developed herein pave the road for designing and building more efficient prothesis for osseointegration between the host bone and prothesis in revision THA.

American Psychological Association (APA)

Man, Zhentao& Sha, Dan& Sun, Shui& Li, Tao& Li, Bin& Yang, Guang…[et al.]. 2016. In Vitro Bioactivity Study of RGD-Coated Titanium Alloy Prothesis for Revision Total Hip Arthroplasty. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099102

Modern Language Association (MLA)

Man, Zhentao…[et al.]. In Vitro Bioactivity Study of RGD-Coated Titanium Alloy Prothesis for Revision Total Hip Arthroplasty. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099102

American Medical Association (AMA)

Man, Zhentao& Sha, Dan& Sun, Shui& Li, Tao& Li, Bin& Yang, Guang…[et al.]. In Vitro Bioactivity Study of RGD-Coated Titanium Alloy Prothesis for Revision Total Hip Arthroplasty. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099102

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1099102