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Effects of Bufei Yishen Granules Combined with Acupoint Sticking Therapy on Pulmonary Surfactant Proteins in Chronic Obstructive Pulmonary Disease Rats
Joint Authors
Jian-sheng, Li
Ya, Li
Tian, Yange
Dong, Yuqiong
Yao, Fengjia
Mao, Jing
Li, Linlin
Wang, Lili
Luo, Shan
Wang, Minghang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our previous studies have demonstrated the beneficial effects of Bufei Yishen granules combined with acupoint sticking therapy (the integrated therapy) in chronic obstructive pulmonary disease (COPD), but the underlying mechanism remains unclear.
Dysfunction of pulmonary surfactant proteins (SPs, including SP-A, SP-B, SP-C, and SP-D) may be included in pathophysiology of COPD.
This study aimed to explore the mechanism of the integrated therapy on SPs.
COPD rat models were established.
The treatment groups received Bufei Yishen granules or acupoint sticking or their combination.
Using aminophylline as a positive control drug.
The levels of SPs in serum, BALF, and lung were measured.
The results showed that the integrated therapy markedly reduced the levels of SPs in serum and increased these indicators in the lung.
The integrated therapy was better than aminophylline in reducing the levels of SPs and was better than Bufei Yishen granules in reducing SP-A, SP-C, and SP-D in serum.
The integrated therapy was better than aminophylline and Bufei Yishen granules in increasing SP-A, SP-B, and SP-D mRNA in the lung.
SP-A and SP-D in BALF were positively correlated with PEF and EF50.
The levels of SPs are associated with airway limitation.
The beneficial effects of the integrated therapy may be involved in regulating pulmonary surfactant proteins.
American Psychological Association (APA)
Tian, Yange& Jian-sheng, Li& Ya, Li& Dong, Yuqiong& Yao, Fengjia& Mao, Jing…[et al.]. 2016. Effects of Bufei Yishen Granules Combined with Acupoint Sticking Therapy on Pulmonary Surfactant Proteins in Chronic Obstructive Pulmonary Disease Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099140
Modern Language Association (MLA)
Tian, Yange…[et al.]. Effects of Bufei Yishen Granules Combined with Acupoint Sticking Therapy on Pulmonary Surfactant Proteins in Chronic Obstructive Pulmonary Disease Rats. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099140
American Medical Association (AMA)
Tian, Yange& Jian-sheng, Li& Ya, Li& Dong, Yuqiong& Yao, Fengjia& Mao, Jing…[et al.]. Effects of Bufei Yishen Granules Combined with Acupoint Sticking Therapy on Pulmonary Surfactant Proteins in Chronic Obstructive Pulmonary Disease Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099140