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Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer
Joint Authors
Woodward, Wendy
Caceres, Sara
Peña, Laura
Silvan, Gema
Illera, Maria J.
Reuben, James M.
Illera, Juan C.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Canine inflammatory mammary cancer (IMC) shares clinical and histopathological characteristics with human inflammatory breast cancer (IBC) and has been proposed as a good model for studying the human disease.
The aim of this study was to evaluate the capacity of female and male mice to reproduce IMC and IBC tumors and identify the hormonal tumor environment.
To perform the study sixty 6–8-week-old male and female mice were inoculated subcutaneously with a suspension of 106 IPC-366 and SUM149 cells.
Tumors and serum were collected and used for hormonal analysis.
Results revealed that IPC-366 reproduced tumors in 90% of males inoculated after 2 weeks compared with 100% of females that reproduced tumor at the same time.
SUM149 reproduced tumors in 40% of males instead of 80% of females that reproduced tumors after 4 weeks.
Both cell lines produce distant metastasis in lungs being higher than the metastatic rates in females.
EIA analysis revealed that male tumors had higher T and SO4E1 concentrations compared to female tumors.
Serum steroid levels were lower than those found in tumors.
In conclusion, IBC and IMC male mouse model is useful as a tool for IBC research and those circulating estrogens and intratumoral hormonal levels are crucial in the development and progression of tumors.
American Psychological Association (APA)
Caceres, Sara& Peña, Laura& Silvan, Gema& Illera, Maria J.& Woodward, Wendy& Reuben, James M.…[et al.]. 2016. Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099159
Modern Language Association (MLA)
Caceres, Sara…[et al.]. Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099159
American Medical Association (AMA)
Caceres, Sara& Peña, Laura& Silvan, Gema& Illera, Maria J.& Woodward, Wendy& Reuben, James M.…[et al.]. Steroid Tumor Environment in Male and Female Mice Model of Canine and Human Inflammatory Breast Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099159