Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction
Joint Authors
Secomb, Timothy W.
Smith, Shane P.
Hong, Brian D.
Moulton, Michael J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-03
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objectives.
To better understand the etiology of HFpEF in a controlled human population, regional time-varying strains were computed using echocardiography speckle tracking in patients with heart failure with a preserved ejection fraction and normal subjects.
Methods.
Eleven normal volunteers and ten patients with echo-graded diastolic dysfunction and symptoms of heart failure were imaged with echocardiography and longitudinal, circumferential, and rotational strains were determined using speckle-tracking.
Diastolic strain rate was also determined.
Patient demographics and echo-derived flows, volumes, and pressures were recorded.
Results.
Peak longitudinal and circumferential strain was globally reduced in patients ( p < 0.001 ), when compared to controls.
The patients attained peak longitudinal and circumferential strain at a consistently later point in systole than controls.
Rotational strains were not different in most LV regions.
Early diastolic strain rate was significantly reduced in the patients ( p < 0.001 ).
LV mass and wall thickness were significantly increased in the patients; however ejection fraction was preserved and stroke volume was diminished ( p < 0.001 ).
Conclusions.
This study shows that patients with HFpEF have reduced early diastolic strain rate and reduced peak strain that is regionally homogeneous and that they also utilize a longer fraction of systole to achieve peak axial strains.
American Psychological Association (APA)
Smith, Shane P.& Secomb, Timothy W.& Hong, Brian D.& Moulton, Michael J.. 2016. Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction. BioMed Research International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099191
Modern Language Association (MLA)
Smith, Shane P.…[et al.]. Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction. BioMed Research International No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1099191
American Medical Association (AMA)
Smith, Shane P.& Secomb, Timothy W.& Hong, Brian D.& Moulton, Michael J.. Time-Dependent Regional Myocardial Strains in Patients with Heart Failure with a Preserved Ejection Fraction. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1099191
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099191