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QualitativeChemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids
Joint Authors
Malkan, Umit Yavuz
Koluman, Ahmet
Akar, Nejat
Haznedaroglu, Ibrahim C.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Introduction.
Ankaferd hemostat (ABS) is the first topical haemostatic agent involving the red blood cell-fibrinogen interactions.
The antihemorrhagic efficacy of ABS has been tested in controlled clinical trials.
The drug induces the formation of an encapsulated complex protein web with vital erythroid aggregation.
The aim of this study is to detect the essential toxicity profile and the antioxidant molecules inside ABS.
Methods.
The pesticides were analyzed by GC-MS and LC-MS.
The determination by ICP-MS after pressure digestion was performed for the heavy metals.
HPLC was used for the detection of mycotoxins.
Dioxin Response Chemically Activated Luciferase Gene Expression method was used for the dioxin evaluation.
TOF-MS and spectra data were evaluated to detect the antioxidants and other molecules.
Results.
TOF-MS spectra revealed the presence of several antioxidant molecules (including tocotrienols, vitamin E, tryptophan, estriol, galangin, apigenin, oenin, 3,4-divanillyltetrahydrofuran, TBHQ, thymol, BHA, BHT, lycopene, glycyrrhetinic acid, and tomatine), which may have clinical implications in the pharmacobiological actions of ABS.
Conclusion.
The safety of ABS regarding the presence of heavy metals, pesticides, mycotoxins, GMO and dioxins, and PCBs was demonstrated.
Thus the present toxicological results indicated the safety of ABS.
The antioxidant content of ABS should be investigated in future studies.
American Psychological Association (APA)
Koluman, Ahmet& Akar, Nejat& Malkan, Umit Yavuz& Haznedaroglu, Ibrahim C.. 2016. QualitativeChemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099194
Modern Language Association (MLA)
Koluman, Ahmet…[et al.]. QualitativeChemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099194
American Medical Association (AMA)
Koluman, Ahmet& Akar, Nejat& Malkan, Umit Yavuz& Haznedaroglu, Ibrahim C.. QualitativeChemical Analyses of Ankaferd Hemostat and Its Antioxidant Content in Synthetic Gastric Fluids. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099194
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099194