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Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway
Joint Authors
Wang, Yanzhen
Cai, Guangsheng
Teng, Lirong
Chen, Yiling
Zhang, Xinrui
An, Shengshu
Wang, Xue
Wang, Di
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Tricholoma matsutake, one of widely accepted functional mushrooms, possesses various pharmacological activities, and its antitumor effect has become an important research point.
Our study aims to evaluate the cytotoxicity activities of T.
matsutake aqueous extract (TM) in HepG2 and SMMC-7721 cells.
In in vitro experiments, TM strikingly reduced cell viability, promoted cell apoptosis, inhibited cell migration ability, induced excessive generation of ROS, and caused caspases cascade and mitochondrial membrane potential dissipation in hepatocellular carcinoma cells.
In in vivo experiments, 14-day TM treatment strongly suppressed tumor growth in HepG2 and SMMC-7721-xenografted nude mice without influence on their body weights and liver function.
Furthermore, TM increased the levels of cleaved poly-ADP-ribose polymerase (PARP), Bad, and Bax and reduced the expressions of B-cell lymphoma 2 (Bcl-2) in treated cells and tumor tissues.
All aforementioned results suggest that caspase-dependent mitochondrial apoptotic pathways are involved in TM-mediated antihepatocellular carcinoma.
American Psychological Association (APA)
Wang, Yanzhen& Chen, Yiling& Zhang, Xinrui& Cai, Guangsheng& An, Shengshu& Wang, Xue…[et al.]. 2016. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099206
Modern Language Association (MLA)
Wang, Yanzhen…[et al.]. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1099206
American Medical Association (AMA)
Wang, Yanzhen& Chen, Yiling& Zhang, Xinrui& Cai, Guangsheng& An, Shengshu& Wang, Xue…[et al.]. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099206