Gamma-Ray Treatment of Echinococcus Protoscoleces prior to Implantation in Mice Reduces Echinococcosis

Abstract EN

Echinococcosis is a serious parasitic disease caused by Echinococcus tapeworms.

Protoscoleces are sometimes released during surgical treatment for hydatid cysts, causing the recurrence of echinococcosis.

Protoscoleces may be susceptible to radiation therapy.

In this study Echinococcus protoscoleces were cultured in vitro and then divided into four different γ-ray irradiation dose groups (10 Gy, 20 Gy, 40 Gy, and 80 Gy) and a blank group.

The protoscoleces were then implanted into the abdominal cavity of mice.

Four months later, we observed that the incidence and weight of cysts declined with the increase of irradiation dose.

γ-ray irradiation can suppress the generation of Echinococcus originated from protoscolex, the reason of which is due to the damaging to the structure of Echinococcus.

Irradiation may prevent echinococcosis recurrence after surgical removal of hydatid cysts.