Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach
Joint Authors
Quiroz-Castañeda, Rosa Estela
Amaro-Estrada, Itzel
Rodríguez-Camarillo, Sergio Darío
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-17
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
In order to understand the genetic diversity of A.
marginale, several efforts have been made around the world.
This rickettsia affects a significant number of ruminants, causing bovine anaplasmosis, so the interest in its virulence and how it is transmitted have drawn interest not only from a molecular point of view but also, recently, some genomics research have been performed to elucidate genes and proteins with potential as antigens.
Unfortunately, so far, we still do not have a recombinant anaplasmosis vaccine.
In this review, we present a landscape of the multiple approaches carried out from the genomic perspective to generate valuable information that could be used in a holistic way to finally develop an anaplasmosis vaccine.
These approaches include the analysis of the genetic diversity of A.
marginale and how this affects control measures for the disease.
Anaplasmosis vaccine development is also reviewed from the conventional vaccinomics to genome-base vaccinology approach based on proteomics, metabolomics, and transcriptomics analyses reported.
The use of these new omics approaches will undoubtedly reveal new targets of interest in the near future, comprising information of potential antigens and the immunogenic effect of A.
marginale proteins.
American Psychological Association (APA)
Quiroz-Castañeda, Rosa Estela& Amaro-Estrada, Itzel& Rodríguez-Camarillo, Sergio Darío. 2016. Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach. BioMed Research International،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1099222
Modern Language Association (MLA)
Quiroz-Castañeda, Rosa Estela…[et al.]. Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach. BioMed Research International No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1099222
American Medical Association (AMA)
Quiroz-Castañeda, Rosa Estela& Amaro-Estrada, Itzel& Rodríguez-Camarillo, Sergio Darío. Anaplasma marginale: Diversity, Virulence, and Vaccine Landscape through a Genomics Approach. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1099222
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099222