Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests
Joint Authors
Alvarado, Jorge L.
Leschot, Andrés
Olivera-Nappa, Álvaro
Salgado, Ana-María
Rioseco, Hernán
Lyon, Carolina
Vigil, Pilar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-29
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Delphinidin anthocyanins have previously been associated with the inhibition of glucose absorption.
Blood glucose lowering effects have been ascribed to maqui berry (Aristotelia chilensis) extracts in humans after boiled rice consumption.
In this study, we aimed to explore whether a standardized delphinidin-rich extract from maqui berry (Delphinol) affects glucose metabolism in prediabetic humans based on glycemia and insulinemia curves obtained from an oral glucose tolerance test (OGTT) after a challenge with pure glucose.
Volunteers underwent four consecutive OGTTs with at least one week washout period, in which different doses of Delphinol were administered one hour before glucose intake.
Delphinol significantly and dose-dependently lowered basal glycemia and insulinemia.
Lower doses delayed postprandial glycemic and insulinemic peaks, while higher doses reversed this tendency.
Glycemia peaks were dose-dependently lowered, while insulinemia peaks were higher for the lowest dose and lower for other doses.
The total glucose available in blood was unaffected by treatments, while the total insulin availability was increased by low doses and decreased by the highest dose.
Taken together, these open exploratory results suggest that Delphinol could be acting through three possible mechanisms: by inhibition of intestinal glucose transporters, by an incretin-mediated effect, or by improving insulin sensitivity.
American Psychological Association (APA)
Alvarado, Jorge L.& Leschot, Andrés& Olivera-Nappa, Álvaro& Salgado, Ana-María& Rioseco, Hernán& Lyon, Carolina…[et al.]. 2016. Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099227
Modern Language Association (MLA)
Alvarado, Jorge L.…[et al.]. Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099227
American Medical Association (AMA)
Alvarado, Jorge L.& Leschot, Andrés& Olivera-Nappa, Álvaro& Salgado, Ana-María& Rioseco, Hernán& Lyon, Carolina…[et al.]. Delphinidin-Rich Maqui Berry Extract (Delphinol®) Lowers Fasting and Postprandial Glycemia and Insulinemia in Prediabetic Individuals during Oral Glucose Tolerance Tests. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099227
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099227