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Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study
Joint Authors
Feng, Ling
Svarer, Claus
Madsen, Karine
Ziebell, Morten
Dyssegaard, Agnete
Ettrup, Anders
Hansen, Hanne Demant
Lehel, Szabolcs
Yndgaard, Stig
Paulson, Olaf Bjarne
Knudsen, Gitte Moos
Pinborg, Lars Hageman
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study aims at developing a simulation system that predicts the optimal study design for attaining tracer steady-state conditions in brain and blood rapidly.
Tracer kinetics was determined from bolus studies and used to construct the system.
Subsequently, the system was used to design inputs for bolus infusion (BI) or programmed infusion (PI) experiments.
Steady-state quantitative measurements can be made with one short scan and venous blood samples.
The GABAA receptor ligand [C11]Flumazenil (FMZ) was chosen for this purpose, as it lacks a suitable reference region.
Methods.
Five bolus [C11]FMZ-PET scans were conducted, based on which population-based PI and BI schemes were designed and tested in five additional healthy subjects.
The design of a PI was assisted by an offline feedback controller.
Results.
The system could reproduce the measurements in blood and brain.
With PI, [C11]FMZ steady state was attained within 40 min, which was 8 min earlier than the optimal BI (B/I ratio = 55 min).
Conclusions.
The system can design both BI and PI schemes to attain steady state rapidly.
For example, subjects can be [C11]FMZ-PET scanned after 40 min of tracer infusion for 40 min with venous sampling and a straight-forward quantification.
This simulation toolbox is available for other PET-tracers.
American Psychological Association (APA)
Feng, Ling& Svarer, Claus& Madsen, Karine& Ziebell, Morten& Dyssegaard, Agnete& Ettrup, Anders…[et al.]. 2016. Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099240
Modern Language Association (MLA)
Feng, Ling…[et al.]. Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099240
American Medical Association (AMA)
Feng, Ling& Svarer, Claus& Madsen, Karine& Ziebell, Morten& Dyssegaard, Agnete& Ettrup, Anders…[et al.]. Design of Infusion Schemes for Neuroreceptor Imaging: Application to [11C]Flumazenil-PET Steady-State Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099240
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099240