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Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside
Joint Authors
Trujillo, Xochitl
Bañales-Martínez, Luis R.
Sánchez-Parada, María G.
Torres-Mendoza, Blanca M.
Armendáriz-Borunda, Juan
Zúñiga-González, Guillermo M.
Zamora-Perez, Ana Lourdes
Gómez-Meda, Belinda Claudia
Lemus-Varela, María de Lourdes
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Genotoxic exposure to chemical substances is common, and nursing mothers could transmit harmful substances or their metabolites to their offspring through breast milk.
We explored the possibility of determining genotoxic effects in the erythrocytes of breastfeeding rat pups whose mothers received a genotoxic compound while nursing.
Ten groups of female rats and five pups per dam were studied.
The control group received sterile water, and the experimental groups received one of three different doses of cyclophosphamide, colchicine, or cytosine-arabinoside.
Blood smears were prepared from samples taken from each dam and pup every 24 h for six days.
There were increased numbers of micronucleated erythrocytes (MNEs) and micronucleated polychromatic erythrocytes (MNPCEs) in the samples from pups in the experimental groups (P<0.02) and increased MNPCE frequencies in the samples from the dams (P<0.05).
These results demonstrate the vertical transmission of the genotoxic effect of the compounds tested.
In conclusion, assessing MNEs in breastfeeding neonate rats to assess DNA damage may be a useful approach for identifying genotoxic compounds and/or cytotoxic effects.
This strategy could help in screening for therapeutic approaches that are genotoxic during the lactation stage and these assessments might also be helpful for developing preventive strategies to counteract harmful effects.
American Psychological Association (APA)
Gómez-Meda, Belinda Claudia& Bañales-Martínez, Luis R.& Zamora-Perez, Ana Lourdes& Lemus-Varela, María de Lourdes& Trujillo, Xochitl& Sánchez-Parada, María G.…[et al.]. 2016. Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099243
Modern Language Association (MLA)
Gómez-Meda, Belinda Claudia…[et al.]. Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099243
American Medical Association (AMA)
Gómez-Meda, Belinda Claudia& Bañales-Martínez, Luis R.& Zamora-Perez, Ana Lourdes& Lemus-Varela, María de Lourdes& Trujillo, Xochitl& Sánchez-Parada, María G.…[et al.]. Micronucleated Erythrocytes in Peripheral Blood from Neonate Rats Exposed by Breastfeeding to Cyclophosphamide, Colchicine, or Cytosine-Arabinoside. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099243