Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation
Joint Authors
Fujii, Tatsuyoshi
Fujii, Noriyoshi
Choi, Jong Weon
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Studies on neutrophil gelatinase-associated lipocalin (NGAL) as an iron-regulatory protein are limited.
This study investigated the relationships between plasma NGAL levels and indices of anemia in 187 patients with systemic inflammation.
Plasma NGAL levels were significantly higher in patients with anemia versus in patients without anemia (185 ng/mL versus 98 ng/mL; P < 0.001).
Serum iron levels were lower in patients with NGAL > 156 ng/mL than in those with NGAL ≤ 156 ng/mL (27.4 ± 25.3 µg/dL versus 58.1 ± 43.5 µg/dL; P < 0.001).
In a receiver operating characteristic curve, the diagnostic ability of NGAL to identify anemia was superior to that of high-sensitivity C-reactive protein [0.712 (95% CI, 0.618–0.787) versus 0.649 (95% CI, 0.573–0.744); P < 0.01].
In a multivariate logistic regression analysis, the elevated NGAL level was significantly associated with the presence of anemia after adjusting for potential confounders [odds ratio, 1.30 (95% CI, 1.07–2.58); P = 0.010].
In conclusion, enhanced NGAL production may contribute to the development of anemia in patients with systemic inflammation.
American Psychological Association (APA)
Choi, Jong Weon& Fujii, Tatsuyoshi& Fujii, Noriyoshi. 2016. Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099253
Modern Language Association (MLA)
Choi, Jong Weon…[et al.]. Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099253
American Medical Association (AMA)
Choi, Jong Weon& Fujii, Tatsuyoshi& Fujii, Noriyoshi. Elevated Plasma Neutrophil Gelatinase-Associated Lipocalin Level as a Risk Factor for Anemia in Patients with Systemic Inflammation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099253