Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus
Joint Authors
Kim, Shin-Yoon
Kim, Tae-Ho
Lee, Sang-Han
Baek, Seung-Hoon
Bae, Sang-Cheol
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Osteonecrosis of the femoral head (ONFH) is a complex and multifactorial disease that is influenced by a number of genetic factors in addition to environmental factors.
Some autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and inflammatory bowel disease (IBD), are associated with the development of ONFH.
Complement receptor type 2 (CR2) is membrane glycoprotein which binds C3 degradation products generated during complement activation.
CR2 has many important functions in normal immunity and is assumed to play a role in the development of autoimmune disease.
We investigated whether CR2 gene polymorphisms are associated with risk of ONFH in SLE patients.
Eight polymorphisms in the CR2 gene were genotyped using TaqMan™ assays in 150 SLE patients and 50 ONFH in SLE patients (SLE_ONFH).
The association analysis of genotyped SNPs and haplotypes was performed with ONFH.
It was found that three SNPs, rs3813946 in 5′-UTR (untranslated region), rs311306 in intron 1, and rs17615 in exon 10 (nonsynonymous SNP; G/A, Ser639Asn) of the CR2 gene, were associated with an increased risk of ONFH under recessive model ( P values; 0.004~0.016).
Haplotypes were also associated with an increased risk (OR; 3.73~) of ONFH in SLE patients.
These findings may provide evidences that CR2 contributes to human ONFH susceptibility in Korean SLE patients.
American Psychological Association (APA)
Kim, Tae-Ho& Bae, Sang-Cheol& Lee, Sang-Han& Kim, Shin-Yoon& Baek, Seung-Hoon. 2016. Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099254
Modern Language Association (MLA)
Kim, Tae-Ho…[et al.]. Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099254
American Medical Association (AMA)
Kim, Tae-Ho& Bae, Sang-Cheol& Lee, Sang-Han& Kim, Shin-Yoon& Baek, Seung-Hoon. Association of Complement Receptor 2 Gene Polymorphisms with Susceptibility to Osteonecrosis of the Femoral Head in Systemic Lupus Erythematosus. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099254