Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling
Joint Authors
Hirata, Hiroaki
Kawauchi, Keiko
Ebata, Takahiro
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Mechanical microenvironments, such as extracellular matrix stiffness and strain, have crucial roles in cancer progression.
Cells sense their microenvironments with mechanosensing biomolecules, which is accompanied by the modulation of actin cytoskeleton structures, and the signals are subsequently transduced downstream as biochemical signals.
The tumor suppressors p53 and retinoblastoma protein (Rb) are known to prevent cancer progression.
The p53 and Rb signaling pathways are disrupted in many types of cancers.
Here, we review recent findings about the roles of these tumor suppressors in the regulation of mechanosensing biomolecules and the actin cytoskeleton.
We further discuss how dysfunction in the p53- and/or Rb-mediated mechanosignaling pathways is potentially involved in cancer progression.
These pathways might provide good targets for developing anticancer therapies.
American Psychological Association (APA)
Ebata, Takahiro& Hirata, Hiroaki& Kawauchi, Keiko. 2016. Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099257
Modern Language Association (MLA)
Ebata, Takahiro…[et al.]. Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099257
American Medical Association (AMA)
Ebata, Takahiro& Hirata, Hiroaki& Kawauchi, Keiko. Functions of the Tumor Suppressors p53 and Rb in Actin Cytoskeleton Remodeling. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099257