Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro
Joint Authors
Wang, Jieqin
Huang, Yaowei
Hou, Xusheng
Wu, Wenyu
Nie, Lei
Tian, Yinghong
Lu, Yanmeng
Yin, Yanru
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To determine whether bile acids (BAs) affect respiratory functions through the farnesoid X receptor (FXR) expressed in the lungs and to explore the possible mechanisms of BAs-induced respiratory disorder.
Methods.
Primary cultured alveolar epithelial type II cells (AECIIs) of rat were treated with different concentrations of chenodeoxycholic acid (CDCA) in the presence or absence of FXR inhibitor Z-guggulsterone (GS).
Then, expression of FXR in nuclei of AECIIs was assessed by immunofluorescence microscopy.
And ultrastructural changes of the cells were observed under transmission electron microscope and analyzed by Image-Pro Plus software.
Results.
Morphologic damage of AECIIs was exhibited in high BAs group in vitro, with high-level expression of FXR, while FXR inhibitor GS could attenuate the cytotoxicity of BAs to AECIIs.
Conclusions.
FXR expression was related to the morphologic damage of AECIIs induced by BAs, thus influencing respiratory functions.
American Psychological Association (APA)
Wang, Jieqin& Huang, Yaowei& Hou, Xusheng& Wu, Wenyu& Nie, Lei& Tian, Yinghong…[et al.]. 2016. Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099269
Modern Language Association (MLA)
Wang, Jieqin…[et al.]. Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099269
American Medical Association (AMA)
Wang, Jieqin& Huang, Yaowei& Hou, Xusheng& Wu, Wenyu& Nie, Lei& Tian, Yinghong…[et al.]. Morphologic Damage of Rat Alveolar Epithelial Type II Cells Induced by Bile Acids Could Be Ameliorated by Farnesoid X Receptor Inhibitor Z-Guggulsterone In Vitro. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099269