Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease
Joint Authors
Granata, Simona
Zaza, Gianluigi
Dalla Gassa, Alessandra
Bellin, Gloria
Lupo, Antonio
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-21
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Chronic kidney disease (CKD) is an increasing and global health problem with a great economic burden for healthcare system.
Therefore to slow down the progression of this condition is a main objective in nephrology.
It has been extensively reported that microinflammation, immune system deregulation, and oxidative stress contribute to CKD progression.
Additionally, dialysis worsens this clinical condition because of the contact of blood with bioincompatible dialytic devices.
Numerous studies have shown the close link between immune system impairment and CKD but most have been performed using classical biomolecular strategies.
These methodologies are limited in their ability to discover new elements and enable measuring the simultaneous influence of multiple factors.
The “omics” techniques could overcome these gaps.
For example, transcriptomics has revealed that mitochondria and inflammasome have a role in pathogenesis of CKD and are pivotal elements in the cellular alterations leading to systemic complications.
We believe that a larger employment of this technique, together with other “omics” methodologies, could help clinicians to obtain new pathogenetic insights, novel diagnostic biomarkers, and therapeutic targets.
Finally, transcriptomics could allow clinicians to personalize therapeutic strategies according to individual genetic background (nutrigenomic and pharmacogenomic).
In this review, we analyzed the available transcriptomic studies involving CKD patients.
American Psychological Association (APA)
Granata, Simona& Dalla Gassa, Alessandra& Bellin, Gloria& Lupo, Antonio& Zaza, Gianluigi. 2016. Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease. BioMed Research International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1099270
Modern Language Association (MLA)
Granata, Simona…[et al.]. Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease. BioMed Research International No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1099270
American Medical Association (AMA)
Granata, Simona& Dalla Gassa, Alessandra& Bellin, Gloria& Lupo, Antonio& Zaza, Gianluigi. Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1099270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099270