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Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2Bax in Rabbits
Joint Authors
Zhang, Jidong
Zhang, Wen-zhong
Li, Rong
Liu, Song
Ning, Xian-feng
Cai, Shang-lang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We investigated the cardioprotective effect of renal ischemic postconditioning (RI-PostC) and its mechanisms in a rabbit model.
Rabbits underwent 60 min of left anterior descending coronary artery occlusion (LADO) and 6 h of reperfusion.
The ischemia-reperfusion (IR) group underwent LADO and reperfusion only.
In the RI-PostC group, the left renal artery underwent 3 cycles of occlusion for 30 seconds and release for 30 seconds, before the coronary artery was reperfused.
In the RI-PostC + GF109203X group, the rabbits received 0.05 mg/kg GF109203X (protein kinase C inhibitor) intravenously for 10 min followed by RI-PostC.
Light microscopy and electron microscopy demonstrated that the RI-PostC group showed less pronounced changes, a smaller infarct region, and less apoptosis than the other two groups.
Bcl-2 and Bax protein expression did not differ between the IR and RI-PostC + GF109203X groups.
However, in the RI-PostC group, Bcl-2 protein expression was significantly higher and Bax protein expression was significantly lower than in the other two groups (P<0.05).
Changes in heart rate and mean arterial pressure were also smaller in the RI-PostC group than in the other two groups.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
American Psychological Association (APA)
Zhang, Wen-zhong& Li, Rong& Liu, Song& Zhang, Jidong& Ning, Xian-feng& Cai, Shang-lang. 2016. Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2Bax in Rabbits. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099283
Modern Language Association (MLA)
Zhang, Wen-zhong…[et al.]. Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2Bax in Rabbits. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099283
American Medical Association (AMA)
Zhang, Wen-zhong& Li, Rong& Liu, Song& Zhang, Jidong& Ning, Xian-feng& Cai, Shang-lang. Effects of Renal Ischemic Postconditioning on Myocardial Ultrastructural Organization and Myocardial Expression of Bcl-2Bax in Rabbits. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099283