Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer
Joint Authors
Yu, Anthony F.
Raikhelkar, Jayant
Zabor, Emily C.
Tonorezos, Emily S.
Moskowitz, Chaya S.
Adsuar, Roberto
Mara, Elton
Huie, Kevin
Oeffinger, Kevin C.
Steingart, Richard M.
Liu, Jennifer E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity.
2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4±8.8 years; 55% male; mean time since diagnosis: 15.4±9.4 years) previously treated with anthracyclines (mean cumulative dose: 320±124 mg/m2), with (n=52) or without (n=82) mediastinal radiotherapy.
The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively.
Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF.
Indices of LV systolic function were similar regardless of anthracycline dose.
However, GLS was worse (18.0 versus 19.0, p=0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p=0.004) in patients treated with mediastinal radiotherapy.
Mediastinal radiotherapy was associated with reduced GLS (p=0.040) after adjusting for sex, age, and cumulative anthracycline dose.
In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors.
American Psychological Association (APA)
Yu, Anthony F.& Raikhelkar, Jayant& Zabor, Emily C.& Tonorezos, Emily S.& Moskowitz, Chaya S.& Adsuar, Roberto…[et al.]. 2016. Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099287
Modern Language Association (MLA)
Yu, Anthony F.…[et al.]. Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099287
American Medical Association (AMA)
Yu, Anthony F.& Raikhelkar, Jayant& Zabor, Emily C.& Tonorezos, Emily S.& Moskowitz, Chaya S.& Adsuar, Roberto…[et al.]. Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099287