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Prenatal Dexamethasone Exposure Increases the Susceptibility to Autoimmunity in Offspring Rats by Epigenetic Programing of Glucocorticoid Receptor
Joint Authors
Sun, Yanhong
Wan, Xiaoyan
Ouyang, Juan
Xie, Renfeng
Wang, Xueping
Chen, Peisong
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
Prenatal glucocorticoids (GC) can induce long term effects on offspring health.
However, reports and related studies regarding the prolonged effects of prenatal GC on the development of autoimmunity are limited.
Here, we aimed to explore the immunological effects of dexamethasone (DEX) exposure on young adults and whether glucocorticoid receptor (GR) is involved in this process.
Methods.
Wistar rats were given DEX during pregnancy.
Susceptibility to autoimmunity in offspring was assessed using experimental autoimmune encephalomyelitis (EAE) and adjuvant-induced arthritis (AIA) animal models.
To reveal the possible mechanism, glucocorticoid response, GR expression, and methylation status were measured in peripheral blood mononuclear cells (PBMCs).
Results.
Our results showed that the DEX-treated rats had greater susceptibility to EAE (100% versus 62.5%, P<0.05) and AIA (63.6% versus 0%, P<0.05) than saline control group.
Glucocorticoid response and GR expression were decreased in DEX rats.
Significant difference was also found in the methylation levels of GR exon 1-10 to exon 1-11 region.
Conclusions.
Prenatal DEX administration increases the susceptibility to autoimmune diseases, which is potentially mediated by programming GR methylation status and glucocorticoid sensitivity.
American Psychological Association (APA)
Sun, Yanhong& Wan, Xiaoyan& Ouyang, Juan& Xie, Renfeng& Wang, Xueping& Chen, Peisong. 2016. Prenatal Dexamethasone Exposure Increases the Susceptibility to Autoimmunity in Offspring Rats by Epigenetic Programing of Glucocorticoid Receptor. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099298
Modern Language Association (MLA)
Sun, Yanhong…[et al.]. Prenatal Dexamethasone Exposure Increases the Susceptibility to Autoimmunity in Offspring Rats by Epigenetic Programing of Glucocorticoid Receptor. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099298
American Medical Association (AMA)
Sun, Yanhong& Wan, Xiaoyan& Ouyang, Juan& Xie, Renfeng& Wang, Xueping& Chen, Peisong. Prenatal Dexamethasone Exposure Increases the Susceptibility to Autoimmunity in Offspring Rats by Epigenetic Programing of Glucocorticoid Receptor. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099298