Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction
Joint Authors
Yan, Hong
Mao, Qingxiang
Ma, Yongda
Wang, Li
Chen, Xian
Hu, Yi
Ge, Hengjiang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aimed to investigate the endothelial function in a canine model of burn injury combined with seawater immersion.
The model of burn injury was established.
The dogs were randomly divided into four groups including dogs with burn injury (B group), or burn injury combined with seawater immersion (BI group), or only immersion in seawater (I group), or control animals with no injury or immersion (C group).
The circulating endothelial cell (CEC) count and coagulation-fibrinolysis parameters were measured.
The CEC count in B group increased at 4 h, 7 h, and 10 h after injury and then reduced, whereas it continuously increased to a greater extent in BI group (P<0.05).
The von Willebrand factor (vWF) activity, plasminogen activator inhibitor (PAI-1), and the ratio of thromboxane B2 (TXB2) to 6-keto-prostaglandin F1α (6-K-PGF1α) in BI group had a marked increase after injury, and the tissue-type plasminogen activator (tPA) in the BI group decreased.
Microscope observations revealed thrombus formation in lungs of the animals in BI group, but not in C, I, or B groups.
Burn injury causes endothelial dysfunction, and seawater immersion lastingly aggravates this injury, leading to a higher risk of developing thrombosis.
American Psychological Association (APA)
Yan, Hong& Mao, Qingxiang& Ma, Yongda& Wang, Li& Chen, Xian& Hu, Yi…[et al.]. 2016. Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099306
Modern Language Association (MLA)
Yan, Hong…[et al.]. Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099306
American Medical Association (AMA)
Yan, Hong& Mao, Qingxiang& Ma, Yongda& Wang, Li& Chen, Xian& Hu, Yi…[et al.]. Seawater Immersion Aggravates Burn Injury Causing Severe Blood Coagulation Dysfunction. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1099306